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Your Companion in Antibiotic Treatment

Rebalance the Gut Microbiome

GUARD YOUR GUT

Conquering Antibiotics Side-effects

Not all probiotics are the same when it comes to taking them alongside antibiotics. Our Bioflor® offers a unique solution as a yeast-based probiotic that can be safely taken alongside antibiotics without contributing to antibiotic resistance1,2,3.

When antibiotics are taken, they have the potential to kill both harmful bacteria and beneficial bacteria, including bacteria-based probiotics1. This can result in a 25% reduction in gut microbiota diversity, disrupting the balance of gut flora and potentially leading to antibiotic resistance4. In some cases, bacteria-based probiotics can also transmit antibiotic-resistant genes, further exacerbating the issue.

In contrast, yeast-based probiotics like Bioflor® are not affected by antibiotics in the same way1,2. This makes Bioflor® a valuable option for individuals who require antibiotics but still want to maintain a healthy gut flora.
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UNDISPUTABLE EFFICACY

Your Remedy for Acute and Antibiotics Associated Diarrhea

Bioflor®, with its unique strain Saccharomyces boulardii CNCM I-745, offers a distinctive solution for acute and antibiotic-associated diarrhea. It has proven to be effective in reducing the duration and frequency of diarrhea in children5, as well as alleviating symptoms in adults6. This is achieved through various mechanisms7:

  • Anti-toxin action – Degrade or bind to toxins, preventing toxin-induced increases in water in the gut
  • Anti-microbial activity – Stop harmful bacteria from attaching to the lining of the gut or invading gut cells.
  • Anti-inflammatory activity – Reduce inflammation in the gut
  • Altering the gut environment – Restore normal gut functioning by promoting the growth of beneficial gut microorganisms
  • Maintaining gut physiology and immune defenses

When it comes to antibiotic use, Bioflor® has been extensively proven to effectively protect gut flora and promote long-term health1,2, significantly reducing the risk of antibiotic-associated diarrhea (AAD).

Reference:

  1. Neut C, Mahieux S, Dubreuil LJ. Antibiotic susceptibility of probiotic strains: Is it reasonable to combine probiotics with antibiotics?. Med Mal Infect. 2017;47(7):477-483. doi:10.1016/j.medmal.2017.07.001
  2. BIOCODEX. Saccharomyces boulardii CNCM I-745® - Company Core Data Sheet. 2021. Reference: I.2963/EN.
  3. Kaźmierczak-Siedlecka K, Ruszkowski J, Fic M, et al. Saccharomyces boulardii CNCM I-745: A Non-bacterial Microorganism Used as Probiotic Agent in Supporting Treatment of Selected Diseases. Curr Microbiol. 2020;77(9):1987-1996. doi:10.1007/s00284-020-02053-9
  4. Panda S, et al. Short-term effect of antibiotics on human gut microbiota. PloS one. 2014; 9(4): e95476
  5. Feizizadeh S, Salehi-Abargouei A, and Akbari V. Efficacy and safety of Saccharomyces boulardii for acute diarrhea. Pediatrics. 2014. 134(1): e176-e191.
  6. Höchter, W, Chase D and Hagenhoff G. Saccharomyces boulardii in acute adult diarrhoea. Efficacy and tolerance of treatment. Münch Med Wochenschr. 1990; 132: 188-92
  7. McFarland, LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World journal of gastroenterology: WJG. 2010; 16(18): 2202.